| Name |
DNMT1
|
| Type |
histone modification
|
| Species |
Mus musculus
|
| Tissue |
Brains
|
| Experiment Method |
real-time PCR,Western blot analysis
|
| Up/Down |
Down
|
| Pro/Anti |
NA
|
| Funtion Description |
Cerebral levels of DNMT1 and MeCP2 were significantly reduced in mice exposed to Pb early in life, whereas the expression of DNMT3a was not altered. Levels of MAT2a were increased in the Pb-exposed mice across the lifespan. H3K9Ac and H3K4me2, involved in
|
| Regulation Gene |
DNMT1;MeCP2;H3K9Ac;H3K4me2
|
| Year |
2016
|
| Pubmed ID |
27239543
|
| Title |
Developmental lead exposure and lifespan alterations in epigenetic regulators and their correspondence to biomarkers of Alzheimer's disease.
|
| Drug |
NA
|
| Disease |
AD
|
| Environment Factors |
Pb exposure
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|