| Name |
DNMT1
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
PC3, U2OS, HEK-293T, and normal human diploid fibroblasts IMR90 cells
|
| Experiment Method |
Immunofluorescence,Quantitative real-time PCR
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Accordingly, treatment of tumor cells with inhibitors of DNA methylation reversed resistance to PML-induced senescence. Further, CDK inhibition with palbociclib promoted autophagy-dependent degradation of the DNA methyltransferase DNMT1. Lastly, we found
|
| Regulation Gene |
CDK4
|
| Year |
2016
|
| Pubmed ID |
27206849
|
| Title |
A CDK4/6-Dependent Epigenetic Mechanism Protects Cancer Cells from PML-induced Senescence.
|
| Drug |
NA
|
| Disease |
PML
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
GSE70923
|