Details
| Name | Dot1l |
| Type | histone modification |
| Species | Mus musculus |
| Tissue | bone |
| Experiment Method | PCR |
| Up/Down | differential expression |
| Pro/Anti | NA |
| Funtion Description | Both Dot1l-deficient strains exhibit a phenotype characterized by joint remodeling with extensive osteophyte formation and ectopic ossification upon ageing, indicating accelerated development of spontaneous osteoarthritis. |
| Regulation Gene | DOT1L |
| Year | 2019 |
| Pubmed ID | 30513362 |
| Title | Increased susceptibility to develop spontaneous and post-traumatic osteoarthritis in Dot1l-deficient mice. |
| Drug | NA |
| Disease | Osteoarthritis |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |