| Name |
Drd2
|
| Type |
histone modification
|
| Species |
Mus musculus
|
| Tissue |
brain
|
| Experiment Method |
qRT-pCR, Western blot, ChIP
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Further, histone acetylation was reduced while histone tri-methylation was increased at specific lysine residues of H3 and H4 within the Drd2 promoter in the striatum of aged mice. HDAC inhibitors, particularly VPA, restored striatal D2R protein levels an
|
| Regulation Gene |
Drd2
|
| Year |
2017
|
| Pubmed ID |
28421257
|
| Title |
Histone deacetylase inhibitors reverse age-related increases in side effects of haloperidol in mice.
|
| Drug |
valproic acid (VPA), haloperidol(HAL)
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|