A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name EHMT1/2
Type histone modification
Species Mus musculus
Tissue prefrontal cortex
Experiment Method RT-PCR
Up/Down Up
Pro/Anti NA
Funtion Description in the late-stage familial Alzheimer's disease (FAD) mouse model, repressive histone H3 dimethylation at lysine 9 (H3K9me2) and euchromatic histone methyltransferases EHMT1 and EHMT2 were significantly elevated in the prefrontal cortex, a key cognitive re
Regulation Gene EHMT1/2
Year 2019
Pubmed ID 30668640
Title Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer's disease.
Drug NA
Disease FAD
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA