| Name |
ERCC6
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
lens anterior capsule membrane
|
| Experiment Method |
qRT-PCR,Western blot assay,Immunohistochemistry,pyrosequencing,Luciferase reporter vectors and assay,Electrophoretic mobility shift assay (EMSA),Chromatin immunoprecipitation (ChIP) Assay
|
| Up/Down |
Up
|
| Pro/Anti |
NA
|
| Funtion Description |
mRNA and protein expression of ERCC6 in lens tissue (LECs) were lower in ARNCs than those in the controls. This reduction corresponded to methylation of a CpG site at the ERCC6 promoter and histone modifications (methylation and acetylation) nearby this s
|
| Regulation Gene |
ERCC6
|
| Year |
2016
|
| Pubmed ID |
27231489
|
| Title |
Ultraviolet-B induces ERCC6 repression in lens epithelium cells of age-related nuclear cataract through coordinated DNA hypermethylation and histone deacetylation.
|
| Drug |
NA
|
| Disease |
ARNC
|
| Environment Factors |
UVB radiation
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|