Details
| Name | Ezh2 |
| Type | histone modification |
| Species | Mus musculus |
| Tissue | bone |
| Experiment Method | ChIP-qPCR, qRT-PCR |
| Up/Down | Up |
| Pro/Anti | Anti |
| Funtion Description | Ezh2 maintains the repression of key cell senescence inducer genes through H3K27me3, and deletion of Ezh2 in early pubertal mice results in premature cellular senescence. The levels of p16 INK4a (Fig. 4h) and p21 CIP1 (Fig. 4i) were significantly increase |
| Regulation Gene | p16-INK4a, p21-CIP1 |
| Year | 2017 |
| Pubmed ID | 29101351 |
| Title | Programmed cell senescence in skeleton during late puberty. |
| Drug | 0 |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |