| Name |
Foxa2 promoter
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
lung
|
| Experiment Method |
RT-Q-PCR, ChiP, Western blot
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
The mRNA level of Foxa2 was downregulated in both replicative and premature senescent cells. We further found the increased DNA methylation level and new methylation at CpG sites in the promoter with 43.6% of methylated CpG islands in premature senesce
|
| Regulation Gene |
Foxa2
|
| Year |
2013
|
| Pubmed ID |
23391216
|
| Title |
The involvement of epigenetic silencing of Foxa2 in cellular replicative and premature senescence induced by hydrogen peroxide.
|
| Drug |
0
|
| Disease |
null
|
| Environment Factors |
H2O2
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|