| Name |
G9a
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
colon
|
| Experiment Method |
RT-PCR, Flow cytometry assay, Western blot, Immunofluorescence
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Overexpression of G9a promoted CRC cells proliferation and colony formation, whereas knockdown of G9a inhibited CRC cells proliferation.Depletion of G9a increased the rate of chromosome aberration, induced DNA double strand breaks and CRC cells senescence
|
| Regulation Gene |
rH2AX
|
| Year |
2015
|
| Pubmed ID |
25595900
|
| Title |
Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation.
|
| Drug |
SN-38, CPT
|
| Disease |
colorectal cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|