| Name |
H2A
|
| Type |
histone modification
|
| Species |
Mus musculus
|
| Tissue |
Mouse embryonic fibroblasts
|
| Experiment Method |
ChIP;Western Blotting;qPCR
|
| Up/Down |
NA
|
| Pro/Anti |
NA
|
| Funtion Description |
We have used a cellular model of conditionally inactive polycomb E3 ligases (RING1A and RING1B), which monoubiquitylate lysine 119 of histone H2A (H2AK119Ub), to examine DNA replication in unperturbed cells. We identify slow elongation and fork stalling d
|
| Regulation Gene |
H2A
|
| Year |
2015
|
| Pubmed ID |
26272920
|
| Title |
Polycomb RING1A- and RING1B-dependent histone H2A monoubiquitylation at pericentromeric regions promotes S-phase progression
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|