Details
| Name | H2AX |
| Type | histone modification |
| Species | Homo sapiens |
| Tissue | HEK293, HCT116 and PC-3 |
| Experiment Method | qRT-PCR |
| Up/Down | Down |
| Pro/Anti | Pro |
| Funtion Description | Formation of gammaH2AX and MDC1 radiation-induced foci was impaired in Hsp72-depleted cells, which in turn enhanced DNA damage, resulting in sensitization of cells to gamma-radiation and doxorubicin. These effects of Hsp72 knockdown were dependent on acti |
| Regulation Gene | null |
| Year | 2010 |
| Pubmed ID | 20062073 |
| Title | HSP72 depletion suppresses gammaH2AX activation by genotoxic stresses via p53/p21 signaling. |
| Drug | 0 |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |