| Name |
H3S28
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
WI-38hTERT-RAF-ER cells
|
| Experiment Method |
qRT-PCR,Immunofluorescence,Chromatin immunoprecipitation,Western blots
|
| Up/Down |
Down
|
| Pro/Anti |
NA
|
| Funtion Description |
We show that MSK1 mediates histone H3S28 phosphorylation at the INK4AB/ARF locus and contributes to the rapid transcriptional activation of p15(INK4B) and p16(INK4A) in human cells despite the presence of the repressive H3K27me3 mark. Furthermore, we show
|
| Regulation Gene |
INK4
|
| Year |
2016
|
| Pubmed ID |
27385346
|
| Title |
MSK1 triggers the expression of the INK4AB/ARF locus in oncogene-induced senescence.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|