| Name |
HDAC
|
| Type |
histone modification
|
| Species |
Mus musculus
|
| Tissue |
brain
|
| Experiment Method |
PCR, Cell proliferation assay, Western blot, Immunofluorescence
|
| Up/Down |
Down
|
| Pro/Anti |
Anti
|
| Funtion Description |
EGCG reduced B-amyloid (AB) accumulation in vitro and rescued cognitive deterioration in senescence-accelerated mice P8 (SAMP8) via intragastric administration of low- and high-dose EGCG (5 and 15 mg/kg, respectively) for 60 days.The AD brain has decrease
|
| Regulation Gene |
NEP, APP
|
| Year |
2015
|
| Pubmed ID |
25882496
|
| Title |
(-)-Epigallocatechin-3-gallate attenuates cognitive deterioration in Alzheimer's disease model mice by upregulating neprilysin expression.
|
| Drug |
epigallocatechin-3-gallate (EGCG)
|
| Disease |
Alzheimer's disease
|
| Environment Factors |
NA
|
| Circulating |
1
|
| Variant |
NA
|
| High-throughput |
NA
|