Details
| Name | HDAC |
| Type | histone modification |
| Species | Homo sapiens |
| Tissue | NA |
| Experiment Method | ChIP,PCR |
| Up/Down | Down |
| Pro/Anti | Anti |
| Funtion Description | Lsh represses endogenous p16(INK4a) expression by recruiting HDAC to establish a repressive chromatin structure at the p16(INK4a) promoter, which in turn delays cell senescence. |
| Regulation Gene | INK4a |
| Year | 2009 |
| Pubmed ID | 19561196 |
| Title | Senescence delay and repression of p16INK4a by Lsh via recruitment of histone deacetylases in human diploid fibroblasts. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |