| Name |
HDAC1
|
| Type |
histone modification
|
| Species |
Mus musculus
|
| Tissue |
lung
|
| Experiment Method |
Western blot, Cell proliferation assay
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Our results showed that hyperoxia exposure resulted in alveolar hypoplasia and was associated with decreased HDAC1 and HDAC2 and increased p53 and p21 expression. Furthermore, AZM did not confer protection against hyperoxia-induced alveolar changes. Th
|
| Regulation Gene |
p53, p21
|
| Year |
2011
|
| Pubmed ID |
21270677
|
| Title |
Hyperoxia impairs alveolar formation and induces senescence through decreased histone deacetylase activity and up-regulation of p21 in neonatal mouse lung.
|
| Drug |
azithromycin (AZM)
|
| Disease |
alveolar hypoplasia
|
| Environment Factors |
hyperoxia
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|