Details
| Name | HDAC1 |
| Type | histone modification |
| Species | Zebrafish |
| Tissue | cardiac |
| Experiment Method | RNA-Seq,RT-Qpcr |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | the DHS-derivative sphinganine-1-phosphate (DHS1P) directly inhibits HDAC1, causing an aberrant elevation in histone acetylation and transcription levels, leading to DNA damage |
| Regulation Gene | HDAC1 |
| Year | 2019 |
| Pubmed ID | 30886000 |
| Title | Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart. |
| Drug | SPHK2 |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |