A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name HMG
Type histone modification
Species Mus musculus
Tissue liver
Experiment Method acid-urea polyacrylamide slab gel electrophoresis
Up/Down Down
Pro/Anti NA
Funtion Description Methylation of HMG proteins decreased drastically in old rats. Whereas spermine inhibited the methylation of total HMG proteins in young rats, it had no effect in old age. On the contrary, sodium butyrate did not change the incorporation of methyl groups
Regulation Gene NA
Year 1989
Pubmed ID 2927415
Title Age-specific methylation of high-mobility-group proteins of the rat liver and its modulation by spermine and sodium butyrate
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA