A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name ARHGAP1
Type gene
Species Mus musculus
Tissue MEF
Experiment Method other
Up/Down NA
Pro/Anti Pro
Funtion Description Natural aging of WT mice is marked with increased Cdc42 activity in various tissues. Among the negative regulators of Cdc42, gene targeting of Cdc42 GTPase-activating protein (Cdc42GAP) results in constitutively elevated Cdc42-GTP level in diverse tissues
Regulation Gene NA
Year 2007
Pubmed ID 17227869
Title Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA