| Name |
ID2
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
NIH3T3 fibroblasts, HeLa cells, MDA-MB-468 breast cancer cell line and two humanfibroblasts cell lines (HF1 and HF2)
|
| Experiment Method |
PCR, Flow cytometry assay, Western blot
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Histone H3 senses cellular redox changes through glutathionylation of Cys, which increases during cell proliferation and decreases during aging. Glutathionylation of histone H3 affects nucleosome stability structure leading to a more open chromatin str
|
| Regulation Gene |
HIST1H3A, PCNA, and Id2
|
| Year |
2013
|
| Pubmed ID |
23541030
|
| Title |
Histone h3 glutathionylation in proliferating mammalian cells destabilizes nucleosomal structure.
|
| Drug |
Biotin labeled glutathione ethyl ester (BioGEE)
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|