| Name |
INK4
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
Human gastric cancer cell lines MKN28, AGS and SGC-7901
|
| Experiment Method |
ChIP;Western Blotting;qPCR
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
We investigated the effects of EZH2 depletion on alteration of histone methylation pattern. In gastric cancer cells, INK4/ARF locus was activated to certain extent in consequence of a decrease of H3K27me3 along it caused by EZH2 silence, which contributed
|
| Regulation Gene |
INK4
|
| Year |
2015
|
| Pubmed ID |
26004298
|
| Title |
Enhancer of zeste homolog 2 depletion induces cellular senescence via histone demethylation along the INK4/ARF locus
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|