Details
| Name | Jarid1a |
| Type | histone modification |
| Species | Homo sapiens |
| Tissue | eyes |
| Experiment Method | RT-qPCR, ChiP |
| Up/Down | Down |
| Pro/Anti | Pro |
| Funtion Description | Our results show that Jarid1a/b-mediated H3K4 demethylation contributes to silencing of retinoblastoma target genes in senescent cells, suggesting a mechanism by which retinoblastoma triggers gene silencing. Therefore, we link the Jarid1a and Jarid1b |
| Regulation Gene | MCM5, Jarid1a, Jarid1b |
| Year | 2012 |
| Pubmed ID | 22615382 |
| Title | H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence. |
| Drug | 0 |
| Disease | retinoblastoma |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |