| Name |
JMJD3
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
PC-3 and LNCaP cells
|
| Experiment Method |
Immunofluorescence, Chromatin Immunoprecipitation, Western blot, qRT-pCR
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
We found triptolide to enhance H3K27me3 levels by down-regulating JMJD3 and UTX and also H3K9me3 through up-regulation of SUV39H1. Our results indicate that triptolide exerts anti-tumor effects including PCa cell senescence at least partially through incr
|
| Regulation Gene |
JMJD3, UTX
|
| Year |
2017
|
| Pubmed ID |
28952292
|
| Title |
Triptolide Promotes Senescence of Prostate Cancer Cells Through Histone Methylation and Heterochromatin Formation.
|
| Drug |
Triptolide
|
| Disease |
Prostate Cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|