| Name |
Klotho promoter
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
muscle samples
|
| Experiment Method |
qPCR,Western blots,Immunohistochemistry,Targeted bisulfite sequencing,Methylation-specific PCR
|
| Up/Down |
Up
|
| Pro/Anti |
NA
|
| Funtion Description |
Klotho experiences increased methylation of CpG sites in its promoter region, which is associated with gene silencing, and increases in a repressive histone mark, H3K9me2. Expression of a klotho transgene in mdx mice restored their longevity, reduced musc
|
| Regulation Gene |
Klotho
|
| Year |
2016
|
| Pubmed ID |
27154199
|
| Title |
Klotho gene silencing promotes pathology in the mdx mouse model of Duchenne muscular dystrophy.
|
| Drug |
NA
|
| Disease |
Duchenne muscular dystrophy (DMD)
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|