| Name |
Lag3
|
| Type |
histone modification
|
| Species |
Mus musculus
|
| Tissue |
brain, liver
|
| Experiment Method |
RNA-seq, qRT-PCR, ChIP-seq, other
|
| Up/Down |
Up
|
| Pro/Anti |
Anti
|
| Funtion Description |
Amyloid pathology impaired histone acetylation and decreased expression of plasticity genes, while aging altered H4K12 acetylation-linked differential splicing at the intron-exon junction in neurons, but not nonneuronal cells.
|
| Regulation Gene |
C4b, Pcdhb9, BC061194, Ankrd22, Lag3
|
| Year |
2015
|
| Pubmed ID |
26280576
|
| Title |
HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models.
|
| Drug |
SAHA
|
| Disease |
Alzheimer's disease
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
GSE63942, GSE63943, GSE63944
|