| Name |
ASAH1
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
Human epithelial melanoma A375 cells
|
| Experiment Method |
Crisp/Cas9;real-time quantitative PCR;Immunocytochemistry, senescence and apoptosis assays;Flow cytometry;Cell invasion assay and soft agar assay
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Importantly,ASAH1-null cells also lose the ability to form cancer-initiating cells and to undergo self-renewal, which is suggestive of a key role for AC in maintaining malignancy and self-renewal of invasive melanoma cells. The results suggest that AC inh
|
| Regulation Gene |
NA
|
| Year |
2017
|
| Pubmed ID |
28785021
|
| Title |
Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells
|
| Drug |
NA
|
| Disease |
melanoma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|