Details
| Name | Nat4 |
| Type | histone modification |
| Species | Yeast |
| Tissue | NA |
| Experiment Method | ChIP, Western blot |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | Consistent with this, (i) Nat4 expression is downregulated and the levels of N-acH4 within chromatin are reduced upon CR, (ii) constitutive expression of Nat4 and maintenance of N-acH4 levels reduces the extension of lifespan mediated by CR, |
| Regulation Gene | Nat4 |
| Year | 2016 |
| Pubmed ID | 27799288 |
| Title | Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity. |
| Drug | 0 |
| Disease | NA |
| Environment Factors | caloric restriction |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |