Details
| Name | Nkx3.2 |
| Type | histone modification |
| Species | Mus musculus |
| Tissue | renal cortical |
| Experiment Method | RT-PCR,Western blot |
| Up/Down | Down |
| Pro/Anti | Anti |
| Funtion Description | SIRT6 induced the expression of GATA5, a novel regulator of blood pressure, through inhibiting Nkx3.2 transcription by deacetylating histone H3K9, thereby regulating GATA5-mediated signaling pathways to prevent endothelial injury,SIRT6 has pleiotropic pro |
| Regulation Gene | GATA5,SIRT6,Nkx3.2 |
| Year | 2019 |
| Pubmed ID | 30894089 |
| Title | Endothelial SIRT6 Is Vital to Prevent Hypertension and Associated Cardiorenal Injury Through Targeting Nkx3.2-GATA5 Signaling. |
| Drug | NA |
| Disease | hypertension |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |