| Name |
p16
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
NA
|
| Experiment Method |
RT-qPCR, ChiP, Flow cytometry assay, Western blot
|
| Up/Down |
Up
|
| Pro/Anti |
Anti
|
| Funtion Description |
These immortalized (transformed) MSCs showed further enhanced DNA methylation of the p16(INK4a) gene by increased H3K9me. Ezh2 knockdown with shRNA eliminated H3K27me-mediated DNA methylation of the p16(INK4a) gene in presenescent MSCs, but had no effe
|
| Regulation Gene |
p16(INK4a)
|
| Year |
2012
|
| Pubmed ID |
22873822
|
| Title |
H3K9me-enhanced DNA hypermethylation of the p16INK4a gene: an epigenetic signature for spontaneous transformation of rat mesenchymal stem cells.
|
| Drug |
0
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|