| Name |
p21 promoter
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
H1299 (p53/), A549, HepG2, U2OS, HEK293T, and WI-38
|
| Experiment Method |
Western Blotting,Real-time PCR,Immunoprecipitation,GST Pulldown Assay,Ubiquitination Assay,Protein Half-life Assay,ChIP,Reporter Gene Assay,MTT Assay,BrdU Incorporation in Situ,Senescence-associated (SA) B-Gal Staining,Soft Agar Colony Formation Assay
|
| Up/Down |
Down
|
| Pro/Anti |
NA
|
| Funtion Description |
The complex mechanisms of HBP1-mediated repression, activation, and histone methylation are all required to orchestrate senescence and prevent tumorigenesis. The likely consequence is that the HBP1-mediated repression of EZH2 and DNMT1 triggers the global
|
| Regulation Gene |
HBP1
|
| Year |
2016
|
| Pubmed ID |
27129219
|
| Title |
HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|