| Name |
p21 promoter
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
Liver
|
| Experiment Method |
qPCR, ChIP, Cell proliferation assay, Flow cytometry assay, Western blot
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
The results showed SVP inhibited the proliferation of Bel-7402 cells in a dose-dependent manner. Low dose SVP treatment caused a large and flat morphology change, positive SA-B-gal staining, and G0/G1 phase cell cycle arrest in human hepatocarcinoma c
|
| Regulation Gene |
p21
|
| Year |
2014
|
| Pubmed ID |
24304587
|
| Title |
Sodium valproate induces cell senescence in human hepatocarcinoma cells.
|
| Drug |
sodium valproate (SVP)
|
| Disease |
hepatocarcinoma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|