Details
| Name | p27 |
| Type | histone modification |
| Species | Homo sapiens |
| Tissue | PDLSC |
| Experiment Method | Flow Cytometric Analysis,Transwell Assay and Scratch Assay,Co-immunoprecipitation (Co-Ip) and Western Blotting Analyses,Osteogenic Differentiation and Alizarin Red Staining (Ars) Assay,QRT-PCR |
| Up/Down | NA |
| Pro/Anti | Pro |
| Funtion Description | Expression of HDAC6 decreased significantly in replicative senescence and induced SC aging models. Loss-of-function experiments suggested that pharmacologic inhibition of deacetylase activity of HDAC6 accelerated PDLSC senescence and impaired its SC activ |
| Regulation Gene | p27Kip1 |
| Year | 2017 |
| Pubmed ID | 27562218 |
| Title | Declined Expression of Histone Deacetylase 6 Contributes to Periodontal Ligament Stem Cell Aging. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |