| Name |
ATM
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
human diploid fibroblasts
|
| Experiment Method |
Luciferase assay;Western Blotting
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
We detected increased specific activity of p53 protein in AT fibroblasts, which exhibit accelerated telomere loss and undergo premature senescence, compared with normal fibroblasts. We investigated the possibility that poly(ADP-ribose) polymerase is invol
|
| Regulation Gene |
NA
|
| Year |
1997
|
| Pubmed ID |
9312059
|
| Title |
ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|