| Name |
p53
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
normal human keratinocytes
|
| Experiment Method |
Luciferase assay;Western Blotting;ChIP;qPCR
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
The methylation status at the p53 promoter was not altered during senescence, but senescent normal human keratinocytes(NHKs) exhibited notably lower level of acetylated histone 3 (H3) at the p53 promoter in comparison with rapidly proliferating cells. Mor
|
| Regulation Gene |
p53
|
| Year |
2015
|
| Pubmed ID |
26138448
|
| Title |
Regulation of p53 during senescence in normal human keratinocytes
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|