Details
| Name | PAI-1 promoter |
| Type | histone modification |
| Species | Mus musculus |
| Tissue | vessel |
| Experiment Method | Western blot |
| Up/Down | Down |
| Pro/Anti | Anti |
| Funtion Description | SIRT1 overexpression reversed the increased PAI-1 expression in senescent human umbilical vein endothelial cells (HUVECs) and aortas of old mice, accompanied by decreased SA-B-gal activity in vitro and improved endothelial function and reduced arterial st |
| Regulation Gene | PAI-1 |
| Year | 2014 |
| Pubmed ID | 25040736 |
| Title | SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence. |
| Drug | 0 |
| Disease | arterial stiffness |
| Environment Factors | NA |
| Circulating | 1 |
| Variant | NA |
| High-throughput | NA |