A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name PBA
Type histone modification
Species Fly Strains
Tissue The Drosophila strains w1118 and wild-type Canton-S
Experiment Method PCR;Reverse-Northern Blots;Western Blotting of Histones
Up/Down Up
Pro/Anti Pro
Funtion Description We report that feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or reproductive ability. Flies fed PBA show a global increase in histone a
Regulation Gene NA
Year 2001
Pubmed ID 11792861
Title Life extension in Drosophila by feeding a drug
Drug 4-phenylbutyrate
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA