A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name ATM
Type gene
Species Mus musculus
Tissue MEFs
Experiment Method other
Up/Down NA
Pro/Anti NA
Funtion Description The ability of 53BP1 to promote the mobility of dysfunctional telomeres could explain why ATM kinase, its upstream regulator, is required for telomere fusions. Indeed, similar to 53BP1-deficient cells, dysfunctional telomeres failed to gain their maximal
Regulation Gene NA
Year 2008
Pubmed ID 18931659
Title 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA