A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name Per1
Type histone modification
Species Hippocampus
Tissue NA
Experiment Method qRT-PCR
Up/Down differential expression
Pro/Anti NA
Funtion Description the repressive histone deacetylase HDAC3 restricts long-term memory, synaptic plasticity, and experience-induced expression of the circadian gene Per1 in the aging hippocampus without affecting rhythmic circadian activity patterns.
Regulation Gene Per1
Year 2018
Pubmed ID 30127461
Title Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput GSE94832