Details
| Name | PGC1 |
| Type | histone modification |
| Species | Homo sapiens |
| Tissue | NA |
| Experiment Method | western blotting,PCR |
| Up/Down | differential expression |
| Pro/Anti | Pro |
| Funtion Description | acetylation of PGC1a is induced by DNA damage agents such as ionizing radiation, which deregulates mitochondrial mechanisms and metabolism, resulting in acceleration of radiation-induced senescence. |
| Regulation Gene | PGC1a |
| Year | 2018 |
| Pubmed ID | 30016403 |
| Title | Acetylation of PGC1a by histone deacetylase 1 downregulation is implicated in radiation-induced senescence of brain endothelial cells. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |