| Name |
PHF8
|
| Type |
histone modification
|
| Species |
Caenorhabditis elegans
|
| Tissue |
C. elegans
|
| Experiment Method |
PCR,Fluorescence Microscopy,Immunoblot Analysis
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
We identify the conserved histone lysine demethylases jmjd-1.2/PHF8 and jmjd-3.1/JMJD3 as positive regulators of lifespan in response to mitochondrial dysfunction across species. Reduction of function of the demethylases potently suppresses longevity and
|
| Regulation Gene |
jmjd-1.2 / PHF8 and jmjd-3.1 / JMJD3
|
| Year |
2016
|
| Pubmed ID |
27133168
|
| Title |
Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|