| Name |
phosphorylated histone H2AX
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
primary human dermal fibroblasts
|
| Experiment Method |
ChIP
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
ATR is necessary for the manifestation and maintenance of the senescent phenotype, because depletion of ATR expression before PUVA prevents induction of senescence, and reduction of ATR expression in PUVA-senesced fibroblasts releases cells from growth ar
|
| Regulation Gene |
H2AX
|
| Year |
2006
|
| Pubmed ID |
16436511
|
| Title |
Senescence of human fibroblasts after psoralen photoactivation is mediated by ATR kinase and persistent DNA damage foci at telomeres
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
photosensitizer 8-methoxypsoralen and ultraviolet A radiation (PUVA)
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|