| Name |
protein arginine methyltransferase 6 (PRMT6)
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
NA
|
| Experiment Method |
PCR, ChiP, Western blot
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
We find that knockdown of PRMT6 results in proliferation defects of transformed as well as non-transformed cells, causes G1-phase arrest and induces senescence. Chromatin immuno-precipitation analysis reveals that the p21 gene is a direct target of P
|
| Regulation Gene |
p21
|
| Year |
2013
|
| Pubmed ID |
22904088
|
| Title |
The arginine methyltransferase PRMT6 regulates cell proliferation and senescence through transcriptional repression of tumor suppressor genes.
|
| Drug |
0
|
| Disease |
NA
|
| Environment Factors |
4-OHT
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|