A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name ATM
Type gene
Species Mus musculus
Tissue NA
Experiment Method other
Up/Down NA
Pro/Anti Anti
Funtion Description Somatic stem cell depletion due to the accumulation of DNA damage has been implicated in the appearance of aging-related phenotypes. Hair graying, a typical sign of aging in mammals, is caused by the incomplete maintenance of melanocyte stem cells (MSCs)
Regulation Gene NA
Year 2009
Pubmed ID 19524511
Title Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA