| Name |
r-H2AX
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
Human new born foreskin fibroblasts
|
| Experiment Method |
RNAi;Western Blotting;qPCR
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Here, we show that resveratrol decreases proliferation of BJ cells in a time and dose dependent manner. In addition the increase in senescence associated B-galactosidase (SA-B-gal) activity and methylated H3K9-me indicate the induction of premature senesc
|
| Regulation Gene |
r-H2AX
|
| Year |
2015
|
| Pubmed ID |
25924011
|
| Title |
Resveratrol Induced Premature Senescence Is Associated with DNA Damage Mediated SIRT1 and SIRT2 Down-Regulation
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
resveratrol
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|