| Name |
SA-gal
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
fibroblast strains IMR-90 and SV40-transformed IMR-90
|
| Experiment Method |
RT-PCR
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
N-HDAC activity in the nuclear extracts prepared from old cells (or late-passage cells) was substantially lower than from younger cells.The observation implicated N-HDAC in aging and led us to hypothesize that modulation of N-HDAC activity might affect th
|
| Regulation Gene |
SA-gal
|
| Year |
2001
|
| Pubmed ID |
11814060
|
| Title |
Rapid reversion of aging phenotypes by nicotinamide through possible modulation of histone acetylation
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|