| Name |
SETD2
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
PTECs and HKC8 cell line
|
| Experiment Method |
RT-qPCR,Histone Isolation and Western Blot Analysis,Immunohistochemistry (IHC) Staining
|
| Up/Down |
Down
|
| Pro/Anti |
Anti
|
| Funtion Description |
Consistent with its known function, SETD2 knockdown (SETD-KD) led to loss of H3K36me3 in PTECs,Our results indicate that SETD2 inactivation enables PTECs to bypass the senescence barrier, facilitating a malignant transformation toward ccRCC.
|
| Regulation Gene |
SETD2
|
| Year |
2016
|
| Pubmed ID |
27292023
|
| Title |
Functional Studies on Primary Tubular Epithelial Cells Indicate a Tumor Suppressor Role of SETD2 in Clear Cell Renal Cell Carcinoma.
|
| Drug |
NA
|
| Disease |
Clear Cell Renal Cell Carcinoma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
GSE72792
|