| Name |
SIRT1
|
| Type |
histone modification
|
| Species |
Mus musculus
|
| Tissue |
brain
|
| Experiment Method |
PCR, Western blot, Immunofluorescence
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Mice with targeted deletion of the clock geneBmal1 (Bmal1(-/-)) show disrupted regulation of reactive oxygen species homeostasis, accelerated aging, neurodegeneration and cognitive deficits. Immunoreaction of the redox sensitive histone deacetylase
|
| Regulation Gene |
Bmal1
|
| Year |
2015
|
| Pubmed ID |
26142744
|
| Title |
Premature aging of the hippocampal neurogenic niche in adult Bmal1-deficient mice.
|
| Drug |
0
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|