Details
| Name | SIRT1 |
| Type | histone modification |
| Species | Mus musculus |
| Tissue | blood, brain, heart, kidney, liver, spleen, muscle, and epididymal fat pads |
| Experiment Method | PCR |
| Up/Down | Down |
| Pro/Anti | Anti |
| Funtion Description | SirT7 and SirT1 are stress responsive proteins that may mediate inflammation. The data suggest that metformin may exert its potential antisenescence and anti-inflammatory effects by targeting SirT7 and SirT1 pathways. SirT7 inhibition may allow the hea |
| Regulation Gene | p16, p53 |
| Year | 2015 |
| Pubmed ID | 25871950 |
| Title | Lipopolysaccharides-Induced Inflammatory Response in White Blood Cells Is Associated with Alterations in Senescence Mediators: Modulation by Metformin. |
| Drug | metformin |
| Disease | NA |
| Environment Factors | NA |
| Circulating | 1 |
| Variant | NA |
| High-throughput | NA |