| Name |
SIRT1
|
| Type |
histone modification
|
| Species |
Homo sapiens
|
| Tissue |
lung, skin
|
| Experiment Method |
RT-PCR, ChiP, Western blot
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
SIRT1 bound to the promoter regions of IL-8 and IL-6, but dissociated from them during cellular senescence.The acetylation of Histone H3 (K9) and H4 (K16) of the IL-8 and IL-6 promoter regions gradually increased during cellular senescence.In SIRT1-deplet
|
| Regulation Gene |
IL-8, IL-6
|
| Year |
2015
|
| Pubmed ID |
25635860
|
| Title |
SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation.
|
| Drug |
0
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|