| Name |
SIRT1
|
| Type |
histone modification
|
| Species |
Mus musculus
|
| Tissue |
NA
|
| Experiment Method |
RT-PCR, Luciferase reporter assay, pulldown assay
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Inhibition of Sirt1 by caveolin-1 is induced by free radicals and promotes cellular senescence and secretion of tumorigenic IL-6 in fibroblasts.The caveolin-1/Sirt1/IL-6 signaling pathway contributes to explain the ability of senescent cells to stimulate
|
| Regulation Gene |
p53, IL-6
|
| Year |
2015
|
| Pubmed ID |
25512378
|
| Title |
Oxidative stress-induced inhibition of Sirt1 by caveolin-1 promotes p53-dependent premature senescence and stimulates the secretion of interleukin 6 (IL-6).
|
| Drug |
0
|
| Disease |
NA
|
| Environment Factors |
oxidation
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|