Details
| Name | SIRT1 |
| Type | histone modification |
| Species | Mus musculus |
| Tissue | lung |
| Experiment Method | qRT-PCR |
| Up/Down | Down |
| Pro/Anti | Pro |
| Funtion Description | Mechanistically, SIRT1 reduces p27(Kip1) expression by decreasing p27(Kip1) protein stability through the ubiquitin-proteasome pathway.In addition, SIRT1 silencing suppresses non-small cell lung cancer (NSCLC) proliferation and induces senescence in a p27 |
| Regulation Gene | p27(Kip1) |
| Year | 2014 |
| Pubmed ID | 25143434 |
| Title | SIRT1 inactivation evokes antitumor activities in NSCLC through the tumor suppressor p27. |
| Drug | 0 |
| Disease | non-small cell lung cancer |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |